Dual Function of Microglia for Blood Brain Barrier (IMAGE)

Nagoya University

Dual Function of Microglia for Blood Brain Barrier

Caption

Microglia express tight junction molecule (CLDN5) to maintain BBB integrity in early phase and molecule for phagocytosis (CD68) to impair the BBB function in late phase of systemic inflammation. Microglia phagocytose astrocyte end feet which is one of the components of BBB.

Credit

Hiroaki Wake

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