Representative dual-isotope SPECT/CT images of mice and correlation between 111In and 177Lu signal in tumor volume. (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Representative dual-isotope SPECT/CT images of mice and correlation between 111In and 177Lu signal in tumor volume.

Caption

(A) Representative dual-isotope SPECT/CT images of mice 71 h after intravenous administration of 111In-anti-γH2AX-TAT (5 MBq, 5 μg) and 72 h after intravenous administration of 177Lu-DOTATATE (20 MBq, 0.33 μg). Tumor is indicated by purple contour in 177Lu image. (B) Correlation between 111In and 177Lu signal in tumor volume in voxel collections based on 177Lu signal quantification in SPECT image of animal in A. (C) Representative dual-isotope SPECT/CT images of mice after administration of 111In-IgG-TAT (5 MBq, 5 μg) and 177Lu-DOTATATE (20 MBq, 0.33 μg). Tumor is indicated by purple contour in 177Lu image. (D) Correlation between 111In and 177Lu signal in tumor volume in voxel collections based on 177Lu signal quantification in SPECT image of animal in C.

Credit

Images created by E. O'Neill et al., University of Oxford, United Kingdom.

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