PD vs MSA (IMAGE)

University of Pennsylvania School of Medicine

PD vs MSA

Caption

(A) α-Synuclein aggregations in Parkinson's disease (PD) and multiple system atrophy (MSA) patients. (B) GCI-α-Syn and LB-α-Syn strains do not have cell-type preferences and they can both be initiated by the same misfolded α-Syn seeds (grey spheres), but different intracellular environments of neurons and oligodendrocytes convert these α-Syn seeds to different strains.

Credit

Virginia Lee, PhD, Perelman School of Medicine, University of Pennsylvania; Nature

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