Disaggregation of α-Synuclein Amyloid Fibrils (IMAGE)

Heidelberg University

Disaggregation of α-Synuclein Amyloid Fibrils

Caption

Disaggregation of α-synuclein amyloid fibrils relies on the cooperation of the HSP70 chaperone with its co-chaperones DNAJB1 and HSP110. This cooperation ensures recognition of the fibrils, followed by the correct assembly of the Hsp70 disaggregase machinery on the fibril surface thereby allowing for productive disaggregation.

Credit

Bernd Bukau / Heidelberg University

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