Engineered Antibodies Fight Bacteria, May Stave Off Antibiotic Resistance (2 of 4) (IMAGE)

American Association for the Advancement of Science (AAAS)

Engineered Antibodies Fight Bacteria, May Stave Off Antibiotic Resistance (2 of 4)

Caption

The active binding units of two monoclonal antibodies (anti-Psl and anti-PcrV) were incorporated into a new form of bispecific antibody resulting in a novel bispecific multifunctional antibody structure with three antibacterial mechanisms of action against Pseudomonas aeruginosa. This single molecule, MEDI3902, was shown to possess more potent protective antibacterial activity in comparison to the mixture of monoclonal antibodies. This image relates to a paper that appeared in the Nov. 12, 2014, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A. DiGiandomenico at MedImmune, LLC in Gaithersburg, Md., and colleagues was titled, "A multifunctional bispecific antibody protects against Pseudomonas aeruginosa."

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MedImmune LLC

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