Schematic Diagram Showing How WISP1 Impairs Insulin Action in Myotubes and Hepatocytes\ (IMAGE)

Deutsches Zentrum fuer Diabetesforschung DZD

Schematic Diagram Showing How WISP1 Impairs Insulin Action in Myotubes and Hepatocytes\

Caption

During obesity, WISP1 VAT expression and WISP1 serum levels increase. In vitro, physiological concentrations of WISP1 impair insulin action on phosphorylation of IRβ, Akt and GSK3β in myotubes and reduce insulin-mediated phosphorylation of IRβ, Akt, GSK3β and FOXO1 in hepatocytes (purple arrow downwards). WISP1 abrogates insulin-mediated induction of glycogen synthesis in myotubes (purple arrow downwards) and insulin-induced suppression of gluconeogenic gene expression (purple arrow upwards). Examined effects (solid arrow), potential effects (dotted arrow).

Credit

Les Laboratoires Servier, courtesy of Servier Medical Art (<a target="_blank"href="https://smart.servier.com/">https://smart.servier.com/</a>), reproduced under the Creative Commons Attribution 3.0 France (CC BY 3.0 FR) license (<a target="_blank"href="https://creativecommons.org/licenses/by/3.0/fr/">https://creativecommons.org/licenses/by/3.0/fr/</a>)

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