Lysosomes in Healthy Neurons and in Neurons with Juvenile Batten Disease (IMAGE)

Baylor College of Medicine

Lysosomes in Healthy Neurons and in Neurons with Juvenile Batten Disease

Caption

Lysosomes of healthy neurons prevent accumulation of cellular waste. In juvenile Batten disease, lysosomes clear cellular waste inefficiently, leading to its accumulation. Inhibiting Akt leads to activation of TFEB and enhanced clearance of cellular waste.

Credit

M. Sardiello.

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