Gut Microbes and Autoimmune Eye Disease (IMAGE)
Caption
It is unknown where and how T cells reactive to self antigens residing behind blood-tissue barriers first become activated. New research shows that retina-specific T cells receive an activation signal in the gut from an antigen dependent on commensal microbiota and trigger autoimmunity in the eye.
Credit
Horai and Zarate-Blades et al./<i>Immunity</i> 2015
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