Prion Proteins Changing (VIDEO) Università di Trento This video is under embargo. Please login to access this video. Caption The video shows the mechanism by which the aggregated and infectious form of the prion protein (red) induces its physiological counterpart (blue) to change conformation. Once the normal form is completely changed, it becomes part of the infectious particle, and itself promotes the misfolding of another normal protein nearby. Once they reach a certain length, the growing aggregates of prions break into multiple smaller fragments, each capable of recruiting additional normal proteins, producing a chain reaction that leads to the accumulation of aggregated prions into the brain of affected patients. Credit Pietro Faccioli Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.