Prion Proteins Changing (VIDEO)
Caption
The video shows the mechanism by which the aggregated and infectious form of the prion protein (red) induces its physiological counterpart (blue) to change conformation. Once the normal form is completely changed, it becomes part of the infectious particle, and itself promotes the misfolding of another normal protein nearby. Once they reach a certain length, the growing aggregates of prions break into multiple smaller fragments, each capable of recruiting additional normal proteins, producing a chain reaction that leads to the accumulation of aggregated prions into the brain of affected patients.
Credit
Pietro Faccioli
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