Professor Chen Carried out Experiments to Compare the Survival Rates of Mice (IMAGE)
Caption
Professor Chen and his team carried out experiments to compare the survival rates of the mice infected with different bacterial strains and different dosages. Testing strains included the Klebsiella variicola strain 15WZ-82 isolated from a patient, classic ST11 Klebsiella pneumonia strain 14WZ-24, ST11 carbapenem-resistant and hypervirulent Klebsiella pneumoniae strain 14WZ-24-TC1 (i.e. the one carrying plasmid from 15WZ-82), HvKP4 and HvKP1088 (both hypervirulence control), as well as classic carbapenem-resistant Klebsiella pneumoniae strain FJ8 (low-virulence control).
Fig a (infection by a higher bacterial dose) shows that although 15WZ-82 exhibited a lower virulence level than the control HvKP strain (mortality rate of the mice infected with 15WZ-82 strain after 120 hours is 80%, while the mice infected with HvKP4 all died after 96 hours), such virulence level was nevertheless much higher than the classic ST11 carbapenem-resistant Klebsiella pneumoniae strain.
Fig b (infection by a lower bacterial dose) shows that the mice infected with 14WZ-24-TC1, i.e., classic ST11 carbapenem-resistant Klebsiella pneumoniae strain carrying plasmid, all died after 120 hours, a level slightly lower than that of hyper-virulent control strain HvKP1088 but far higher than HvKP4; on the contrary, the mice infected with the same dose of 14WZ-24 (classic ST11 Klebsiella pneumonia strain 14WZ-24 which does not carry the plasmid) all survived.
Credit
<i>Nature Microbiology</i> (DOI: 10.1038/s41564-019-0566-7)
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