Is Amyloid-Beta Keeping You Up at Night? (IMAGE)
Caption
Mice which develop amyloid beta (Abeta) deposits in the brain (hippocampus in the left upper figure) showed increased wakefulness (30 minutes per hour during the light phase -- left lower panel) when they are supposed to be sleeping most of the time. In contrast, animals vaccinated with Abeta42 showed almost no pathology in the brain (hippocampus in the right upper panel) with a normal amount of wakefulness (15-20 minutes per hour during the light phase -- right lower panel). This image relates to a paper that appeared in the Sept. 5, 2012, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. J.H. Roh at Washington University School of Medicine in St. Louis, Mo., and colleagues, was titled, "Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of Amyloid-β in Mice with Alzheimer’s Disease Pathology."
Credit
Credit: Figure created by Jee Hoon Roh, M.D., Ph.D.
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