Small Molecule Inhibitor Improves Cat Heart and Lung Function (2 of 3) (IMAGE)

American Association for the Advancement of Science (AAAS)

Small Molecule Inhibitor Improves Cat Heart and Lung Function (2 of 3)

Caption

An FDA-approved HDAC inhibitor named SAHA reduced the size of heart cells and the thickness of ventricular walls in a new cat model of heart failure (right, compared to control in middle). This material relates to a paper that appeared in the Jan. 8, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by M. Wallner at Temple University in Philadelphia, PA; and colleagues was titled, "HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction."

Credit

M. Wallner <i>et al., Science Translational Medicine</i> (2019)

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