New Mutation Linked to Ovarian Cancer Can Be Passed down through Dad (IMAGE)

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New Mutation Linked to Ovarian Cancer Can Be Passed down through Dad

Caption

Fig 1. X-linked model. Schema for X-linked inheritance when cancer status is specific to women (all carrier men are effectively disease censored). Two family patterns with a pair of first-degree affected women are the maternal grandmother (MGM) family and the paternal grandmother (PGM) family. Stratton's paradox implies that PGM families are more likely under X-linkage because a father must pass the variant to all of his daughters. The rates are equal if the variant is autosomal.

Credit

Kevin H. Eng and colleagues

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