Postnatal Maturation of Pancreatic B Cells (IMAGE)

Cell Press

Postnatal Maturation of Pancreatic B Cells

Caption

This visual abstract depicts the Yoshihara et al. report that the postnatal maturation of pancreatic b cells necessary for maximal glucosestimulated insulin secretion is coordinated by the estrogen-related receptor g (ERRg). ERRg drives a transcriptional program promoting mitochondrial oxidative metabolism, and its expression in iPSC-derived b-like cells generates functional b cells in vitro.

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Yoshihara et al./Cell Metabolism 2016

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