Broad-Spectrum Antiviral Probes (IMAGE)
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There is no effective small-molecule therapy for most viruses, including highly pathogenic viruses such as Ebola, which is associated with mortality rates of up to 90 percent following infection. Filone et al, describe compounds that inhibit the replication of genetically diverse viruses, including Ebola. These compounds can limit virus replication (illustrated as green molecules "blocking" spread of orange Ebola virus virions from an infected cell). These molecules represent probes of a central virus function as well as a lead compound for the development of effective broad-spectrum antivirals.
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Image created by Claire Marie Filone and John Connor, Ebola virus micrograph by Chris Reed at USAMRIID.
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