Top-Down Design (IMAGE) Arizona State University Caption Illustration shows the basic process used to design DNA origami nanostructures. First, a wireframe of the intended target design is made. The software then translates this into a plan for the routing of DNA scaffold and staple strands, which assemble to form the desired shape. Credit Biodesign Institute Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.