Blood Stem Cells in a Rush (IMAGE)
Caption
Mende et al. show that a balanced progression through the early and the late G1 cell cycle phase is a key regulator of hematopoietic stem cell function in vivo. In their study, a shortening of the G1 cell cycle phase transit time by the overexpression of CCND1/CDK4 significantly improved hematopoietic stem cell function compared to controls. However, a dramatic reduction of the duration of G1 progression mediated by CCNE1/CDK2 overexpression resulted in the rapid loss of stem cell function. The figure is a metaphoric depiction of the finding that the timing of G1 phase transition is pivotal for human hematopoietic stem cell fate choices.
Credit
Image by Nicole Mende.
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