Reproduction of CAMT Pathology (IMAGE)

Center for iPS Cell Research and Application - Kyoto University

Reproduction of CAMT Pathology

Caption

iPS cells generated from a CAMT patient reproduced the pathology of CAMT, in other words they were to some extent able to differentiate into white blood cells, but showed a marked loss of differentiation into both platelets and erythrocytes. It was established that the absence of thrombopoietin receptors also led to the failure of differentiation from multipotent hematopoietic progenitors to megakaryocyte-erythrocyte bipotent progenitors.

Credit

Koji Eto, Center for iPS Cell Research and Application at Kyoto University

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