Age Related Microbiology Changes (IMAGE) Cell Press Caption This visual abstract represents the findings of Thevaranjan et al. who, using young and old germ-free and conventional mice, demonstrate that age-related microbiota changes drive intestinal permeability, age-associated inflammation, and decreased macrophage function. Reducing TNF levels rescues microbiota changes and protects old mice from intestinal permeability. Credit Thevaranjan et al./<i>Cell Host & Microbe</i> 2017 Usage Restrictions Credit required License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.