p53 Transient State Is a Potential Drug Target against Cancer (IMAGE)

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p53 Transient State Is a Potential Drug Target against Cancer

Caption

Under normal conditions, native p53 protein is folded but when chemicals and/or high pressure are applied the protein may unfold and loose its 3D structure. During the unfolding process, p53 acquires the molten globule conformation that is very prone to aggregation. The presence of p53 aggregates is very harmful for the cell and is associated with cancer development and progression.

Credit

Guilherme A. de Oliveira

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