Caution: Grapefruit Juice May Impose Risk on Patients with Long QT Syndrome and Should Be Avoided (IMAGE)

Elsevier

Caution: Grapefruit Juice May Impose Risk on Patients with Long QT Syndrome and Should Be Avoided

Caption

These four graphs show deviations of the QTc from baseline during different study days with different interventions. The horizontal axis shows the time (in hours) starting after the third baseline ECG. The vertical axis represents changes in QTc (either prolongation or shortening) from baseline (or delta QTc) following a given intervention. The yellow arrow denotes the timing of administration of oral moxifloxacin after the third baseline electrocardiogram and the pink and red arrows denote repeated administration of grapefruit juice. Panel A compares the delta-QTc during the off-drug day before moxifloxacin (in green) and during the off-drug day before grapefruit (in blue). Note that the two graphs are similar, never reaching a statistically significant difference. Panels B and C show the delta QTc among healthy volunteers after receiving moxifloxacin (yellow line) or grapefruit (red line) and the delta QTc during their respective off-drug study day. Panel D shows the delta QTc of long-QT patients after drinking grapefruit (pink line) and during the off-drug day (light green).

Credit

<strong>Heart</strong>Rhythm

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