In the Absence of Gut Bacteria, Food Antigens Boost Allergy Antibody (2 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

In the Absence of Gut Bacteria, Food Antigens Boost Allergy Antibody (2 of 2)

Caption

Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota. Studies with germ-free (GF) mice fed an elemental (antigen-free) diet (designated as antigen-free mice) revealed that spontaneous IgE elevation in GF and antibiotics-treated mice is driven by food antigens through the generation of IL-4-producing TFH cells in gut-associated lymphoid tissues, Peyer's patches and mesenteric lymph nodes (MLNs). Early life is highly favorable for TFH cell generation in response to food antigens. This material relates to a paper that appeared in the May 22nd, 2019, issue of Science Advances, published by AAAS. The paper, by S.-W. Hong at Institute for Basic Science (IBS) in Pohang, Republic of Korea, and colleagues was titled, "Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota."

Credit

[Credit: Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea]

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.