Response to FLIP of Caged Calcium (IMAGE)

RIKEN

Response to FLIP of Caged Calcium

Caption

Time-lapse differential interference contrast (DIC) images of chick dorsal root ganglion growth cones. Attractive Ca2+ signals were generated by FLIP of caged Ca2+ at red spots. (left panels) A control axon grows toward the left when caged calcium is released on the left side of the growth cone. (right panels) After injecting the RIHCR peptide, an axon fails to grow towards the left, despite the release of caged calcium on that side. Time in minutes after the onset of repetitive FLIP (3 s interval) is shown. The scale bar represents 10 mm. FLIP: focal laser-induced photolysis; RIHCR: RyR and IP3R Highly Conserved Region.

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RIKEN

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