Engineered Antibodies Fight Bacteria, May Stave Off Antibiotic Resistance (4 of 4) (VIDEO)
Caption
The anti-Psl (blue) monoclonal antibody targets an abundant exopolysaccharide "slime layer" coating around the bacteria. This mAb is lower affinity (quick-on/quick-off) interaction, but because the Psl target is so abundant and repetitive, the mAb skips from one binding event to another across the surface of the bacteria. The anti-Psl mAb (blue) corona around the bacteria, prevent the bacteria from attaching to host cells and is also a signal and handle for the body's killer cells to engulf, kill and clear the bacteria. This video relates to a paper that appeared in the Nov. 12, 2014, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A. DiGiandomenico at MedImmune, LLC in Gaithersburg, Md., and colleagues was titled, "A multifunctional bispecific antibody protects against Pseudomonas aeruginosa."
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MedImmune LLC
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