Figure. Dead Zone Formation (IMAGE) Kanazawa University Caption Top left: Negative feedback loop in the Drosophila circadian clock system. Top right: Phase response curve (blue dotted) and transcription rate of Timeless mRNA (red solid) in simulations. A positive value of phase shift indicates phase advance, whereas a negative value indicates phase delay. Bottom left: Negative feedback loop in the mammalian circadian clock system. Bottom right: Phase response curve (blue dotted) and translation rate of PERIOD protein (red solid) in simulations. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.