Nanoparticle Delivers DNA (IMAGE)

Case Western Reserve University

Nanoparticle Delivers DNA

Caption

Modified ECO nanoparticles bind to interphotoreceptor retinoid-binding protein (IRBP), which transports them to the target cells in the retinal pigment epithelium (RPE.) The ECO is taken up by the cell through endocytosis but the nanoparticles escape endosomes and release the RPE 65 DNA into the nucleus. The RPE65 gene is then expressed by the RPE call, protecting the photoreceptor cells and preserving vision.

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Zheng-Rong Lu

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