Figure Scheme of Recon 2M.2 (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

Figure Scheme of Recon 2M.2

Caption

This is a scheme of Recon 2M.2 development and its use in reconstructing personal genome-scale metabolic models (GEMs). (A) In developing Recon 2M.2, a concept of alternative splicing of human genes was considered, and incorporated into modeling through the computational framework for Gene-Transcript-Protein-Reaction Associations (GeTPRA). (B) Upon development of Recon 2M.2, cancer patient-specific GEMs could be reconstructed using personal biological data (RNA-Seq data). In this study, patient-specific RNA-Seq data were obtained from The Cancer Genome Atlas (TCGA; https://cancergenome.nih.gov/).

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KAIST

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