Enzyme-Activated Imaging Probe Lights up Cancer (IMAGE)

American Association for the Advancement of Science (AAAS)

Enzyme-Activated Imaging Probe Lights up Cancer

Caption

Cancer cells are thought to overproduce enzymes known as cathepsin proteases that promote cancer growth and invasion. A new study reports the use of a protease-activated fluorescent probe to image tumors in mice and from patients with soft tissue sarcoma and breast cancer. This material relates to a paper that appeared in the Jan. 6, 2016, issue of Science Translational Medicine, published by AAAS. The paper, by M.J. Whitley at Duke University Medical Center in Durham, N.C., and colleagues was titled, "A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer."

Credit

C. Bickel / <i>Science Translational Medicine</i>

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