Gene Therapy Regenerates Diseased Liver in Pigs (1 of 3) (IMAGE)

American Association for the Advancement of Science (AAAS)

Gene Therapy Regenerates Diseased Liver in Pigs (1 of 3)

Caption

Schematic of the steps involved in ex vivo gene therapy in FAH-deficient (Fah?/?) pigs, a model of a metabolic liver disorder known as hereditary tyrosinemia type 1. This material relates to a paper that appeared in the July 27, 2016, issue of Science Translational Medicine, published by AAAS. The paper, by R.D. Hickey at Mayo Clinic in Rochester, MN, and colleagues was titled, 'Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1.'

Credit

Hickey <i>et al., Science Translational Medicine</i> (2016)

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