Schematic Representation (IMAGE)

Institute for Basic Science

Schematic Representation

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This is a schematic representation of click reaction-assisted immune cell targeting (CRAIT) strategy used to enhance tumor penetration of drug-loaded NPs. (left, top) Antibodies are pre-injected to label circulating immune cells, and drug-loaded nanoparticles are subsequently administered to target the immune cells via click reaction. (left, bottom) Schematic illustration of tumor microenvironment featuring inflammatory cell recruiting and inhomogeneous blood vessel distribution. (right) Schematic illustration on the principles of CRAIT strategy. Immune cells are labeled by antibodies and subsequently tagged with nanoparticles by a click reaction. The labeled cells transport nanoparticles from tumor periphery to tumor interior.

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