Cryo-EM structures of the original and mutated SARS-CoV-2 spike protein (IMAGE)

Boston Children's Hospital

Cryo-EM structures of the original and mutated SARS-CoV-2 spike protein

Caption

This model shows the structure of the spike protein in its closed configuration, in its original D614 form (left) and its mutant form (G614). In the mutant spike protein, the 630 loop (in red) stabilizes the spike, preventing it from flipping open prematurely and rendering SARS-CoV-2 more infectious.

Credit

Bing Chen, PhD, Boston Children's Hospital

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