LTC4 Synthase Overall Structure (IMAGE)

European Synchrotron Radiation Facility

LTC4 Synthase Overall Structure

Caption

a, Left, front view of LTC4 synthase protomer in ribbon representation showing helices 1–5 in successive coloring. The entire LTC4 synthase polypeptide, except for the last residue (the last four in the GSH-complexed structure), can be traced in the electron density maps. Right, the homotrimer with protomers colored orange, green and blue. Bound glutathione, indicating the position of the active site, is in ball and stick representation. Approximate membrane positions indicated by blue lines. b, Cytosolic view of the trimer, showing the position of the three active sites with loop one covering each binding pocket. Glutathione is shown in ball and stick representation together with modelled detergent (DDM).

Credit

D. Martinez Molina

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