Unveiling Gut Microbes' Influence on Cancer Patient Response to Immunotherapy (IMAGE)
Caption
The group performed fecal microbiome transplant (FMT) studies from responding patients on PD-1 blockade (R) or from non-responding patients (NR). In these studies, mice receiving FMT from R had enhanced systemic and anti-tumor immunity, with more immune cells in the tumor and in the gut of the transplanted animals. Conversely, mice receiving FMT from NR had poor anti-tumor immunity and a paucity of immune cells in the gut. This material relates to a paper that appeared in the 2 November 2017, online issue of <i>Science</i>, published by AAAS. The paper, by V. Gopalakrishnan at University of Texas MD Anderson Cancer Center in Houston, TX, and colleagues was titled, "Gut microbiome impacts response to anti-PD-1 immunotherapy in melanoma patients."
Credit
Dr. Luigi Nezi
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