The In Situ Structure of Parkinson's Disease-Linked LRRK2 (IMAGE)
Caption
State of the art technologies researchers used to finally unveil the structure of LRRK2 inside cells. First, they used fluorescence proteins to find it, then they used a beam of ions to carve out regions that contained LRRK2 filaments, which they imaged using cryo-electron tomography. Finally, they computationally analyzed the data to build models of the protein in high level of detail.
Credit
Villa Lab, UC San Diego
Usage Restrictions
Must be used in conjunction with papers on LRRK2 and Parkinson's disease.
License
Licensed content