The In Situ Structure of Parkinson's Disease-Linked LRRK2 (IMAGE)

University of California - San Diego

The In Situ Structure of Parkinson's Disease-Linked LRRK2

Caption

State of the art technologies researchers used to finally unveil the structure of LRRK2 inside cells. First, they used fluorescence proteins to find it, then they used a beam of ions to carve out regions that contained LRRK2 filaments, which they imaged using cryo-electron tomography. Finally, they computationally analyzed the data to build models of the protein in high level of detail.

Credit

Villa Lab, UC San Diego

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Must be used in conjunction with papers on LRRK2 and Parkinson's disease.

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