Mutations of the Gene SGMS2 were Identified as the Cause of the Disease (IMAGE)

University of Helsinki

Mutations of the Gene SGMS2 were Identified as the Cause of the Disease

Caption

Bone health of the study participants was evaluated by radiographs (A, B) and bone biopsy samples (C, D). The patients had in childhood e.g. recurrent forearm fractures (A) and spinal compression fractures (B). Histological evaluation of the bone biopsies showed (C) that bone structure (green) especially in the cortical bone was abnormally fragile and osteoporotic. More detailed evaluation of the bone biopsies showed that the degree of bone mineralization was reduced and the bone tissue was porous (D), leading to reduced bone strength.

Credit

Outi Mäkitie Lab

Usage Restrictions

The image may only be used with appropriate credit.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.