Regeneration in the Black Substance (IMAGE) University of the Basque Country Caption The histological sections show different degrees of impairment or recuperation of the black substance. This formation is dyed to highlight the enzyme tyrosine hydroxylase (precursor of dopamine) in groups treated with empty microspheres (control group), with microspheres loaded with VEGF (VEGF-MS), with microspheres loaded with GDNF (GDNF-MS) and with microspheres loaded with VEGF and GDNF in a combined way (VEGF+GDNF-MS). The arrow indicates the area of the black substance where there is greater regeneration (greater positivity, browner making). It corresponds to the group treated with microspheres loaded with VEGF and GDNF. Scale bar= 1 mm. Credit UPV/EHU Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.