Globin Gene Globules (IMAGE)
Caption
The evolution of globin gene domain 3-D organization exhibits a tendency to the formation of globular structures. Embryonic and adult globin genes are designated with light grey and dark grey circles, respectively. The major regulatory element (MRE) of the Danio rerio major globin gene locus and α-globin gene domains of warm-blooded vertebrates is designated with red hexagon. The locus control region (LCR) of the β-globin gene domains of warm-blooded vertebrates is designated with a set of red rectangles. Experimentally validated insulators and putative ones are designated with dark blue ellipses and light blue ellipses, respectively. The spatial configuration of the mouse α-globin gene domain and the interaction frequency between the insulators in the chicken α-globin gene domain in embryonic erythroid cells before globin expression switching are currently unknown.
Credit
Razin lab
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