HLO Magnified (IMAGE)

Cincinnati Children's Hospital Medical Center

HLO Magnified

Caption

This confocal microscopic image shows a tiny bioengineered human liver organoid grown in the lab with pluripotent stem cells. The mini-organ is accumulating inflammation and fat lipids (bluish bubble-like shapes), which are hallmarks of fatty liver and Wolman disease. The ability to closely mimic naturally occurring human liver disease in a research laboratory allowed researchers in the U.S. and Japan to determine underlying disease biology and search for much-needed new treatments, they report in Cell Metabolism.

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Cincinnati Children's

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