molecules structure (IMAGE)
Caption
Image 1. (a) Minimum inhibitory concentration of MER or COL against E. coli CKE (MCR-1+, NDM-5+) in the absence or presence of AUR. (b) Structure of the active site of Au-NDM-1 (PDB ID: 6LHE) with the anomalous density peak of Au shown as yellow spheres and water molecules as red spheres. (c) Structure of the active site of Au-MCR-1-S (PDB ID: 6LI6) with the anomalous density peak of Au ion shown as a purple sphere. (d,e) Balb/c mice were given a sub-lethal dose of K. pneumoniae (MCR-1+) and received single dose of administration of vehicle, AUR, COL or their combination. Bacterial loads in the spleen (d) and liver (e) are shown. c, Survival curves showing combination efficacies in the peritonitis infection model. Balb/c mice were infected by a lethal dose of E. coli CKE (MCR-1+, NDM-5+) and received single dose of administration of vehicle, AUR, COL or their combination.
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The University of Hong Kong
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