Figure (IMAGE)

National University of Singapore

Figure

Caption

The shuttling of FHL2 between the focal adhesions and the nucleus in response to substrate stiffness. On soft surfaces, upon phosphorylation by FAK, FHL2 translocates to the nucleus, where it activates the synthesis of p21, cell proliferation inhibitor. On stiff surfaces, FHL2 is found at the focal adhesions.

Credit

Mechanobiology Institute, National University of Singapore

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