Effect of Different Therapies on Cognitive Function and Other Biomarkers (IMAGE)

InSysBio LLC

Effect of Different Therapies on Cognitive Function and Other Biomarkers

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Effect of different therapies on cognitive function and other biomarkers under different hypotheses of amyloid toxicity Two variants of therapy initiation were applied: preclinical stage (70 years, left) and mild Alzheimer disease (AD) stage (75 years, right).(a) Amyloid beta (Ab) toxicity influencing cognitive outcomes (Adas-cog) simulations under different hypotheses. (b) Influence of different treatments on the cognitive function, cerebrospinal fluid (CSF) amyloid and positron emission tomography (PET) DVR with respect to baseline under hypothesis RI, release inhibition.

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