Cell Receptor Signaling Gone Awry Underlies Joint Degeneration in Arthritis (2 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Cell Receptor Signaling Gone Awry Underlies Joint Degeneration in Arthritis (2 of 2)

Caption

Overexpressing the Itgbl1 gene with a viral delivery system in mice with induced osteoarthritis reduced cartilage damage in the knee (fourth row) compared to untreated rodents (second row).This material relates to a paper that appeared in the Oct. 10, 2018, issue of Science Translational Medicine, published by AAAS. The paper, by E.K. Song at Ulsan National Institute of Science and Technology in Ulsan, Republic of Korea; and colleagues was titled, " ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis."

Credit

E.K. Song<i> et al., Science Translational Medicine</i> (2018)

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