Graphical Abstract (IMAGE) AlphaMed Press Caption Single cell Transcriptome-based developmental trajectories reveal developmental abnormalities in glaucoma patient-specific RGCs. A comparison of the developmental trajectories, based on lineage- and stage-specific transcriptional signature of differentiating glaucoma patient (SIX6risk allele)-specific and control iPSCs along the RGC lineage, revealed that the SIX6risk allele RGCs are compromised in mature phenotype and subtype composition, including those that are degeneration resistant, versus controls. Credit AlphaMed Press Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.