Graphical Abstract (IMAGE)

AlphaMed Press

Graphical Abstract

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Single cell Transcriptome-based developmental trajectories reveal developmental abnormalities in glaucoma patient-specific RGCs. A comparison of the developmental trajectories, based on lineage- and stage-specific transcriptional signature of differentiating glaucoma patient (SIX6risk allele)-specific and control iPSCs along the RGC lineage, revealed that the SIX6risk allele RGCs are compromised in mature phenotype and subtype composition, including those that are degeneration resistant, versus controls.

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AlphaMed Press

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