Induced brain microvascular endothelial cells (IMAGE)

Weill Cornell Medicine

Induced brain microvascular endothelial cells

Caption

Induced brain microvascular endothelial cells (IBMECs) (top panel) cultured in 3D assume an epithelial organoid structure and express the epithelial cell marker EPCAM (purple). When they are reprogrammed by overexpression of ETV2, ERG and FLI1, they lose EPCAM expression, acquire vascular markers VE-Cad (red) and PECAM1 (green) and are able to fulfill the function of endothelial cells - forming blood vessels (bottom panel).

Credit

Image courtesy of the Lis lab

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