Titin (IMAGE)

Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

Titin

Caption

Three-dimensional structure of one of the more than 100 immunoglobulin domains in titin. A disulfide bond is highlighted in red between two cysteines brought into proximity by the protein folding. When the immunoglobulin domain is subject to mechanical force, as during muscle stretching or in the diastolic phase of heart contraction, the domain opens up but is prevented from completely unfolding by the presence of the disulfide bond.

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CNIC

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