Neuronal differentiation (IMAGE)

Aarhus University

Neuronal differentiation

Caption

Left side: During normal neuronal differentiation circZNF827 is induced and fine-tunes specific neuronal gene expression by assembly of nuclear transcription regulatory complex consisting of ZNF827 (green ovals "827") and hnRNP K/-L (blue boxes "K" and "L"). This complex limits the transcriptional output from several neuronal genes including Nerve Growth Factor Receptor (NGFR).

Credit

Christian Kroun Damgaard and Anne Kruse Hollensen.

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