Calorie Restriction Graphical Abstract (IMAGE) Cell Press Caption This graphical abstract depicts the effects of a 2-year calorie restriction (CR) trial in healthy, non-obese humans, which found evidence that prolonged CR enhances resting energy efficiency, resulting in decreased oxidative damage to tissues and organs. Credit Redman et al./<i>Cell Metabolism</i> Usage Restrictions Credit Required License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.