Salk science image (IMAGE) Salk Institute Caption Caption: From left: iPSC-derived dentate gyrus (DG)-like neurons (green) from control subject; bipolar lithium responder; and bipolar lithium nonresponder. While the percentage of DG-like neurons is the same for control and bipolar, the gene activation profiles are different and the nonresponder has low levels of Lef1. Credit Salk Institute Usage Restrictions with credit and related coverage. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.