Ossified Vertebral Endplate (IMAGE) Johns Hopkins Medicine Caption In experiments with genetically engineered and old mice, Johns Hopkins Medicine researchers say they have added to evidence that the vast majority of low back pain in people may be rooted in an overgrowth of pain-sensing nerves into spinal cartilaginous tissue. Credit Xu Xao Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.