Transcription-translation coupling representation (IMAGE)
Caption
The 30S subunit of the ribosome can dynamically bind to the nascent mRNA as soon as its binding site emerges from the RNAP. Transcription factors and translation initiation factors assist in the initial binding and retention of the 30S subunit on the mRNA, resulting in the stabilization of an early initiation complex. During translation, the ribosome can follow the leading RNAP, establishing transcription-translation coupling and maintaining optimal transcription speed. In the presence of the ligand preQ1, transcription-translation coupling is disrupted, surprisingly leading to slow transcription.
Credit
Surajit Chatterjee
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